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Sabine Hombach-Klonish MD, PhD

Currently accepting students.

Current Position

Associate Professor, Dept. of Human Anatomy and Cell Sciences

History

Education:

2004 Habilitation, Martin-Luther-University Halle-Wittenberg, Germany
2003 distinction Anatomy, German Medical Council
1994 PhD, Section Pathophysiology, JLU-Giessen, Germany
1991 MD, Justus-Liebig University Giessen, Germany

Achievements and Awards:

1998-2000: Research Postdoctoral Fellowship; Province of Saxony-Anhalt, Germany
2002: Merck European Thyroid von Basedow Research Prize; German Endocrine Society
2009: Murray L. Barr Young Investigator Award; Canadian Association of Anatomy, Neurobiology and Cell Biology (CAANCB)

Research Focus:

Adolescence/childhood thyroid cancer
Developmental protein HMGA2 in thyroid cancer
Environmental Toxicology
3D-telomere architecture in differentiation
Cancer stem cells

Impact of environmental chemicals in hormone-responsive tissues with particular focus on the thyroid gland (NSERC)
Role of relaxin-RXFP1 signaling in cancer metastasis (MHRC Establishment)
S100A4-RAGE signaling as potential of marker for invasiveness in human thyroid cancer (Dept. of Surgery Research Grant Funding)

Relaxin-RXFP1 signaling in angiogenesis and metastasis
Role of S100A4 and RAGE signaling in tumor growth, angiogenesis and metastasis
Role of paracrine factors (relaxin-LGR7 signaling; S100A4-RAGE signaling)
Chromosomal alterations as a result of environmental insult and as cause of endocrine resistance