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Professor, Department of Oral Biology, University of Manitoba
Director, Manitoba Chemosensory Biology (MCSB) Research Group
PhD, University of Manitoba
Postdoc, Massachusetts Institute of Technology
G protein-coupled receptors (GPCRs) constitute the largest known family of cell surface receptors. These receptors transduce signals across the cell membranes in response to diverse extracellular stimuli. GPCRs are involved in fundamental biological processes such as sensing taste, light, odor, and in various other physiological functions. Typically 40% of the prescription pharmaceutical drugs target these GPCRs. The Chelikani laboratory uses genetic, biochemical and biophysical techniques to study the signaling mechanisms of these receptors. The current research focus is on few GPCRs, the human bitter taste receptors and the prostanoid receptors.
Lab webpage: http://home.cc.umanitoba.ca/~chelikan/