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Paul Fernyhough PhD, BSc

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Dr. Fernyhough was born and educated in East London, UK, and performed his B.Sc. degree in Biological Sciences at the University of Essex. Dr. Fernyhough performed his PhD in biochemistry in the department of Biochemistry (department of Sir Hans Krebs) at University of Sheffield in the UK. He also performed postdoctoral research at Colorado State University, Kings College London (department of Maurice Wilkins) and as a Wellcome Trust Postdoctoral Fellow at St Bartholomew’s Medical College (department of Sir John Vane). Drs Krebs, Wilkins and Vane are all Nobel Prize winners. All of these positions spanned 1985-1998. Dr. Fernyhough subsequently worked for 5½ years (1998-2004) as a fully tenured lecturer in the School of Biological Sciences (now the Faculty of Life Sciences) at the University of Manchester. Dr. Fernyhough’s general research interest is in the cell biology underlying neurodegenerative disorders of the peripheral and central nervous systems

Dr. Fernyhough is studying the etiology of the peripheral nerve damage observed in patients with diabetes. In addition he is researching the link between Alzheimer’s disease and Type 2 diabetes. “In patients with Alzheimer’s disease there is an increased risk of developing diabetes and these patients exhibit more severe and accelerated memory loss” says Dr. Fernyhough. Our studies are focused on identifying key signaling pathways that are impaired in animal models of Alzheimer’s disease. A major direction of the lab is to determine whether improper insulin signal transduction in neurons is central to axon and neuronal loss.