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Adjunct Professor, Department of Medical Microbiology, University of Manitoba; Research Scientist, HIV and Human Genetics, National Microbiology Laboratory, Public Health Agency of Canada
M. Sc. (Chinese University of Science and Technology, Beijing, China 1982)
PhD (University of Manitoba, 1987)
My major professional interest is to address important questions in the life sciences with the tools of genetic analysis, molecular biology, biochemistry, and computer-aided analysis of information. My major focus in the recent years has been on uncovering the mechanism of resistance and susceptibility to HIV-1 infection and disease progression, including the influence of host genetic factors in mother-child HIV-1 transmission, and to understand the interplay between host genetics, the human leukocyte antigens (HLA) in particular, and HIV viruses. The aim is to use this knowledge to develop vaccines and therapeutics.
There are many research projects on-going and they can be summarized into several categories: 1. Investigate and characterize genetic basis of resistance and susceptibility to HIV-1 infection and disease progression, including host genetic factors influencing mother-child HIV-1 transmission. The related projects including studying the association of HLA class I and class II, HLA-G, KIR2Dl2/3, KIR3DL1/S1, APOBEC3H etc. with resistance/susceptibility to HIV-1 infection and disease progression, as well as mother-child transmission of HIV-1. 2. Using systems biology approach, such as genome-wide SNPs analysis, exon microarray analysis and pathway analysis to investigate host genetic factors influencing susceptibility to infectious diseases. 3. Studying the diversity and evolution of HIV-1 and host-viral interactions to understand the interplay between host genetics/immunogenetics and HIV-1. 4. identify and characterize T cell epitopes of HLA class I and class II alleles associated with different outcomes of HIV-1. 5. Genotyping and characterization of MHC of none human primates, such as Cynomolgus macaques. 6. Develop and test novel vaccine and prevention ideas for HIV-1. 7. Investigation of genetic basis of heterogeneous host responses to H1N1 Swine influenza A.