A leading contributor of science and knowledge through discoveries.
Currently accepting students.
Associate Professor, Department of Anatomy and Cell Science
1994 Ph.D., Anatomy, Tehran University of Medical Sciences, Tehran, Iran
1991 M.Sc., Anatomy, Mashhad University of Medical Sciences, Mashhad, Iran
1989 B.Sc., Physiotherapy, Faculty of Rehabilitation Sciences, Iran University of Medical
Sciences, Tehran, Iran
My research interests are to understand the cellular and molecular mechanism of:
The well-known architecture and function of the cerebellum provide a remarkable model system for studying the normal and abnormal development of the nervous system. The temporal and spatial dynamics of cerebellar development are exquisitely controlled and as a model this structure combines the simplicity of spinal cord development and the complexity of cerebral cortical formation.
My laboratory utilizes a broad array of sophisticated cellular and molecular techniques including immunocytochemistry (section and whole-mount), in vitro culture systems (primary dissociated cerebellar culture and embryonic explant cultures), axonal tract tracing (anterograde and retrograde), western blotting, and mutant mouse models such as naked ataxic ‘nax’ mutant mice.
The nax mutant is a novel spontaneous recessive mutation in the Acp2 (lysosomal acid phosphatase) gene, and exhibits an ataxic phenotype, combined with growth retardation and delayed hair appearance. Our goal is to elucidate the genetic hierarchy which controls the formation of early cerebellar circuits and to understand how their misregulation could lead to defects of the cerebellum.
We use these basic experimental insights as an inroad to understanding the bases of human brain pathology. It is our hope that our research will stimulate the discovery of novel and efficacious therapies for preventing circuit formation defects in the developing brain.