A leading contributor of science and knowledge through discoveries.

 
← Back to Profiles

Hassan Marzban PhD

  • Phone: 204-789-3467
  • Fax: 204-789-3920
  • Recent Publications
  • Cooperation: University of Manitoba

Currently accepting students.

Current Position

Assistant Professor, Department of Anatomy and Cell Science

History

1994 Ph.D., Anatomy, Tehran University of Medical Sciences, Tehran, Iran

1991 M.Sc., Anatomy, Mashhad University of Medical Sciences, Mashhad, Iran

1989 B.Sc., Physiotherapy, Faculty of Rehabilitation Sciences, Iran University of Medical

Sciences, Tehran, Iran

Research Focus

My research interests are to understand the cellular and molecular mechanism of:

  • neurogenesis and axonogenesis during early cerebellar development.
  • pattern formation in the developing cerebellum.
  • patterned neuronal degeneration in cerebellar disorders.

The well-known architecture and function of the cerebellum provide a remarkable model system for studying the normal and abnormal development of the nervous system. The temporal and spatial dynamics of cerebellar development are exquisitely controlled and as a model this structure combines the simplicity of spinal cord development and the complexity of cerebral cortical formation.

My laboratory utilizes a broad array of sophisticated cellular and molecular techniques including immunocytochemistry (section and whole-mount), in vitro culture systems (primary dissociated cerebellar culture and embryonic explant cultures), axonal tract tracing (anterograde and retrograde), western blotting, and mutant mouse models such as naked ataxic ‘nax’ mutant mice.mice

The nax mutant is a novel spontaneous recessive mutation in the Acp2 (lysosomal acid phosphatase) gene, and exhibits an ataxic phenotype, combined with growth retardation and delayed hair appearance. Our goal is to elucidate the genetic hierarchy which controls the formation of early cerebellar circuits and to understand how their misregulation could lead to defects of the cerebellum.

We use these basic experimental insights as an inroad to understanding the bases of human brain pathology. It is our hope that our research will stimulate the discovery of novel and efficacious therapies for preventing circuit formation defects in the developing brain.