A leading contributor of science and knowledge through discoveries.

← Back to Profiles

Estelle Simons MD, FRCPC

Currently Not Accepting Students.

Current Position

Dr. Estelle Simons is a Professor in the Department of Pediatrics and Child Health and the Department of Immunology at the University of Manitoba.


She obtained her BSc and MD (Honors) from the University of Manitoba, and trained in Pediatrics and in Allergy/Immunology at the University of Washington. She is a Fellow of the Royal College of Physicians of Canada, a Diplomate of the American Board of Pediatrics, and a Diplomate of the American Board of Allergy and Immunology.

She founded the Section of Allergy and Clinical Immunology in the Department of Pediatrics in 1975. She served as Section Head from 1975-2005, and as Training Program Director in Allergy and Clinical Immunology from 1976-1991.

She was one of the first pediatrician Clinician Scientists in Canada, holding the Medical Research Council of Canada’s Queen Elizabeth II Scientist Award from 1975-1981, and the Children’s Hospital Research Foundation/University of Manitoba Bruce Chown Professorship until 2001.

Research Focus

Dr. Simons’ current research is focused on development of a non-invasive epinephrine formulation for treatment of anaphylactic episodes in community settings. With her colleagues, she is developing a rapidly-dissolving tablet containing microcrystals of epinephrine for sublingual administration.

With colleagues, she pioneered the pharmacokinetic/pharmacodynamic approach to the investigation of medications used in allergic diseases such as asthma, allergic rhinitis, urticaria, and anaphylaxis. She conducted innovative clinical pharmacology studies and clinical trials of all the main classes of these medications, including: epinephrine and other adrenergic agonists, inhaled glucocorticoids, leukotriene modifiers, methylxanthines, and antihistamines. She published some of the initial pediatric studies of medications such as epinephrine, salmeterol, formoterol, montelukast, fexofenadine, cetirizine, and levocetirizine.

In addition, with colleagues, she contributed to improved understanding of human interactions with the environment that lead to sensitization to allergens and to allergic diseases, and published the first descriptions of the clinical and immunological characteristics of mosquito saliva-induced anaphylaxis and Skeeter Syndrome (large local reactions to mosquito saliva).

Dr. Simons has authored or co-authored more than 550 original publications which have appeared in The Journal of Allergy and Clinical Immunology, Journal of Immunology, Journal of Pediatrics, Pediatrics, British Medical Journal, Lancet, New England Journal of Medicine, and other indexed peer-reviewed journals. She has also authored or co-authored more than 300 published abstracts.

She has edited or co-edited seven books, including the medical bestseller Histamine and H1-Antihistamines in Allergic Disease (1st and 2nd editions) and Middleton’s Allergy: Principles and Practice (6th and 7th editions), the leading allergy reference textbook used worldwide. She currently edits the Anaphylaxis section of the principal online medical textbook UpToDate, which is used annually by 700,000 physicians.

She has also served on the editorial board of 5 biomedical journals, including the Journal of Allergy and Clinical Immunology (current impact factor 12.047). Since 1991, she has been the contributing editor for allergy/immunology to The Medical Letter.