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Researcher, Children’s Hospital Research Institute of Manitoba; Assistant Professor, Department of Pediatrics and Child Health, University of Manitoba; Senior Consultant, Biostatistics Group, George and Fay Yee Center for Healthcare Innovation
Dr. Sharma was raised in Nova Scotia, attended Medical School at Dalhousie University, (1981-1985), completed a pediatric residency at McGill University/Montreal Children’s Hospital (1985-88), and served as chief resident there in 1988-89. After completing a fellowship in Pediatric Nephrology at the University of Minnesota, Dr. Sharma joined the McGill faculty in 1993. Since 2013, he has been a senior consultant for the Biostatistics Group in the George and Faye Yee Center for Healthcare Innovation (CHI) at the University of Manitoba.
As a biostatistician, Dr. Sharma continues to be actively involved in academic research. This autumn, he became the official Biostatistics Group liaison for CHRIM investigators in the DEVOTION, DREAM, and iCARE consortia, to co-ordinate collaborative efforts.
As a result, his work often has a pediatric focus. In 2014, the Public Health Agency of Canada released their new 2014 WHO Growth Charts for Canada, based on his reanalysis of the original WHO data (Extending World Health Organization weight-for-age reference curves to older children. BMC Pediatrics, 2014). He has also published normative reference tables for central adiposity in North American children and shown them to be better than BMI as predictors of cardio-metabolic risk (LMS tables for waist-circumference and waist-height ratio Z-scores in children aged 5-19y in NHANES III: Association with cardio-metabolic risks. Pediatric Research, 2015).
He is a co-investigator in a multi-center study of pediatric kidney transplant rejection (Urinary metabolomics for non-invasive detection of borderline and acute T cell-mediated rejection in children after kidney transplantation. Am J Transplanation, 2014 ). His interests also include vitamin D supplementation in healthy, breastfed infants (e.g. Randomized dose-response trial of oral vitamin D supplementation with 400, 800, 1200 or 1600 IU/day in breastfed infants: a Canadian experience. JAMA, 2013), developmental pediatrics (Normative Data and Predictors of Leg Muscle Function and Postural Control in Children. Medicine & Science in Sports & Exercise, 2014), bone health (Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada. Clinical Biochemistry, 2015), and health program evaluation (Failure of free vitamin D supplementation program for Quebec infants. Acta Paediatrica, 2015).
His specific statistical interests include growth curves methods for summarizing normative data; multivariate classification techniques (machine learning); and geomapping for assessing the geographic distribution of disease and linking patient locations to census data.
In addition to teaching introductory statistics for medical students, residents, and fellows, Dr. Sharma also conducts workshops on advanced statistical methods for clinical researcher (e.g. propensity score methods for non-randomized, observational data). He is a member of the Pediatric Resident Research Committee, the College of Medicine’s Resident Research Council, and the curriculum development committee for the new pediatric Academic Skills curriculum (ASK, 2016).