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1) Asthma 2) Food allergy 3) Anaphylaxis
Research Question: – management of anaphylaxis in ER; Population of patients being studied: – ER; Expected Outcomes – improved care. Source of Data: Chart review
Research Question: – unique triggers of anaphylaxis; Population of patients being studied: – consultation clinic; Expected Outcomes – awareness. Source of Data: Data collection
Research Question: – asthma education; Population of patients being studied: – adolescents; Expected Outcomes – better delivery of education. Source of Data:
Biochemistry and Medical Genetics
1.) Lysosomal storage disorders; 2.) Genetics; 3.) Population screening
Research Question: – Comparison of human and mouse Bowen-Conradi syndrome phenotype; Population of patients being studied: – Hutterites; Expected Outcomes – Clear understanding if mouse provides a good model. Source of Data: Review of previous ultrasounds and other info
Testing of AAV9 intravenous delivery for correction of the GM2 gangliosidoses
Manuscript is still in preparation
Education and Faculty Development
1.) Feedback/Assessment/Program Evaluation; 2.) Leadership Development/Transitions; 3.) CanMEDS
Research Question: – Development of tools to improve quality of completed preceptor and rotation evaluation forms; Population of patients being studied: – Residents, medical students; Expected Outcomes – Tool to evaluate and teach above skill, better completed preceptor and rotation evaluation forms. Source of Data: Survey; Focus groups.
Research Question: – Perspectives on content for a leadership curriculum in health care; Population of patients being studied: – learners and faculty; Expected Outcomes – Broad stakeholder input on the needs of health care leaders of current and future generations.
In research, have worked with 1
1) – Toxicology; 2) – Emergency Medicine; 3) – Injury Prevention
1) – Metabolic response to exercise; 2) – Complications associated with diabetes; 3) – Adversity, resilience and obesity in children; 4) – Community-based action research for prevention of type 2 diabetes in Aboriginal children
Research Question: – What school and community-level factors protect youth from obesity after a reduction in household; Population of patients being studied: – Children 9 yrs old in the Growing Up in Ireland Study; Expected Outcomes – Manuscript. Source of Data: Database
Are younger children at a greater risk of moderate-severe ATV-related injuries than their older peers?
Abstract, Presentation at a conference and Manuscript (Submitted to JAMA Pediatrics)
Doing a fellowship at SickKids
Can we predict hepatic steatosis using a simple algorithm in a general pediatric setting?
Abstract, Presentation, Manuscript (Submitted to Pediatrics)
Is asthma associated with vascular dysfunction in children?
Does a peer-led healthy living curriculum improve self image in children?
Currently – Maternity leave PGY3
Children’s Hospital Research Institute of Manitoba
1) – Prevention of type 1 diabetes; 2) – Diabetes in pregnancy; 3) – Extra-skeletal effects of vitamin D
Deanne Malenfant (Obstetrics)
Bone health of women following early teenage pregnancy
Abstract and presented at a conference. Manuscript pending.
University of Manitoba
1) – type 2 diabetes; 2) – transition from pediatric to adult care; 3) – interprofessional education and the CanMEDS collaborator role
Evaluation of integration of a foot care nurse in type 2 diabetes clinic: a quality improvement project
Abstract and presentation at conference. manuscript is in preparation
Manitoba Clinic, Winnipeg, Manitoba
Deaths in Children with GH Deficiency and Hypopituitarism in Canada
Abstract and presented at conference. Manuscript: 32. Taback SP, Collu R, Deal CL, Guyda HJ, Salisbury S, Dean HJ, Van Vliet G. Does Growth Hormone Supplementation Affect Adult Height in Turner’s Syndrome? Lancet. 348(9019):25-7, 1996. 33. Taback SP, Dean HJ. Mortality in Canadian Children with Growth Hormone (GH) Deficiency Receiving GH Therapy 1967-1992. The Canadian Growth Hormone Advisory Committee. J Clin Endocrinol Metab. 81(5):1693-6, 1996.
Influenza Vaccine in Children with Type 1 Diabetes
Children’s Hospital, Winnipeg, Manitoba
Endocrine and metabolism
1) – Type 2 diabetes in youth: 2) – Type 1 diabetes in youth; 3) – Vitamin D
Dyslipdemia and other cardiovascular risk factors in a Canadian First Nation Pediatric Population with Type 2 Diabetes
Abstract, presentation at conference and manuscript (24. Sellers EAC, Yung G, Dean HJ. Dyslipidemia and Other Cardiovascular Risk Factors in a Canadian First Nation Pediatric Population with Type 2 Diabetes Mellitus. Pediatr Diabetes 2007 Dec;8(6):384-90 (PMID: 18036065).
Winnipeg Children’s Hospital, Winnipeg, Manitoba
Severe vitamin D deficiency in 6 Canadian First Nation formula-fed infants.
Abstract, presentation at conference and manuscript (Gross ML, Tenenbein M, Sellers EA. Severe vitamin D deficiency in 6 Canadian First Nation formula-fed infants. Int J Circumpolar Health 2013 Apr 16; 72. Doi: 10.3402/ijch.v72i0.20244. (PMID: 23599910).)
Alberta Children’s Hospital, Calgary, Alberta
Blastomycosis of the Central Nervous System in a Child: A Rare Case of Hypopituitarism
Manuscript (40. Abrams E, Dean HJ, Bunge MK, Taback SP, Sellers EA. Blastomycosis of the Central Nervous System in a Child: A Rare Case of Hypopituitarism. J Pediatr Endocrinol Metab 2011;24(9-10):775-7 (PMID: 22145474).
Community setting and Winnipeg Children’s Hospital, Winnipeg, Manitoba
Pediatrics and Child Health
1) – clinical epidemiology; 2) – vital signs; 3) – growth
Research Question: – What vital sign ranges should be used in triage of pediatric emergency patients?; Population of patients being studied: – Pediatric emergency patients; Expected Outcomes – Creation of new vital sign ranges. Source of Data: Database
Research Question: – Would it be possible to identify children at high risk for return to ED and admission by their heart rate and/or respiratory rate at ED discharge; Population of patients being studied: – Pediatric ED patients; Expected Outcomes – We may (or may not) identify a subset of patients at high risk for return/admission at the time of ED discharge. Source of Data: Chart review
Two currently, none in the past
1.) STBBI Prevention of Mother to Child Transmission; 2.) Regional STBBI Testing Patterns and Testing Optimization; 3.) Molecular diagnostics in the immunocompromised host
Research Question: – What are the factors in the discrepant testing rates between GC/Ct and BBP?; Population of patients being studied: – All patients tested for STBBIs in Manitoba in 2012; Expected Outcomes – Data will help direct education to increased and harmonize STBBI testing rates. Source of Data: Database
Clinical and microbiological characteristics of peritoneal dialysis-associated peritonitis (PDAP) and exit site infections (ESI) in pediatric patients in Manitoba from 1992 to 2010
Abstract; Presentation at conference
1) – antimicrobial resistance and stewardship; 2) – blastomycosis; 3) – pertussis and respiratory infections
Research Question: – Review of infant blastomycosis; Population of patients being studied: – case series of infant blasto at WCH. Source of Data: Chart review
Research Question: – Parental attitudes toward H1N1 immunization during 2009 pandemic; Population of patients being studied: – sampling of parents attending MB clinic/Unit 1 clinic (received and not received vaccine); Expected Outcomes – majority received vaccine; most concerns re accessibility. Source of Data: Survey
One in last five years
Description of H1N1 hospitalized cases at WCH
Vancouver Children’s, Vancouver, British Columbia
1) – infectious diseases; 2) – global health; 3) – immigrant health
Research Question: – Evaluation of pediatric data from baseline assessments of MNCH in 8 districts in Northern Karnataka, India; Population of patients being studied: – children under 5 in 8 districts in Northern Karnataka, India. Source of Data: Database
Research Question: – Evaluation of pediatric data from baseline assessments of MNCH and nutrition in Taita Taveta County, Kenya: Population of patients being studied: – Children under 5 in Taita Taveta County, Kenya. Source of Data: Database
Presentation of Malaria in Children to a Canadian Pediatric Centre
Abstract, presentation at conference and manuscript
University of Manitoba and the Winnipeg Regional Health Authority, Winnipeg, Manitoba
Epidemiology of Paediatric Empyemas in Manitoba
Abstract, presentation at conference. Manuscript is in progress
Additional Training (MSc, MBA, PhD, etc)
PhD at University of Manitoba/NML
1) – STBBI Prevention of Mother to Child Transmission; 2) – Regional STBBI Testing Patterns and Testing Optimization; 3) – Molecular diagnostics in the immunocompromised host
Abstract and presentation at conference
1.) Sports and recreation 2.) Injury prevention 3.) Protective equipment
Research Question: – Are academic performance and quality of life compromised after a sport-related concussion among youth returning to the classroom?
Population of patients being studied: – Youth with a sport related concussion. Expected Outcomes – Evidence will help inform a Return to Learn program for Winnipeg schools. Source of Data: Data collection
Research Question: – What is the epidemiology of gymnastics injuries among children and youth Population of patients being studied: – Children and youth who present to the emergency department with a gymnastics injury. Expected Outcomes – Describe how Canadian children are injured while participating in gymnastics and identify any differences between males and females. Source of Data: Chart review
Age and the risk of ATV-related injuries in children and adolescents: Injury patterns and legislative impact assessment through the CHIRPP database.
The Hospital for Sick Children, Toronto, Ontario
1) – BPD and Respiratory Management; 2) – Infection in Neonates; 3) – Quality Improvement in NICU
1) – Clinical Trials; 2) – RSV Prevention; 3) – Medical Education
Research Question: – Compliance with RSV Prophylaxis: Population of patients being studied: – Patients enrolled in MB RSV Program and in CARESS database: Expected Outcomes – comparison of outcomes.
Research Question: – Effectiveness and efficiacy of Neonatal OSCE in testing CanMEDS roles: Population of patients being studied: – Participants in national neonatal OSCE.
Cost of Palivizumab for Standard Categories of Eligibilityin a Canadian Provincial RSV Immunoprophylaxis Program
University of Alberta, Edmonton, Alberta
Use and Evaluation of a Risk Scoring Tool in a Provincial Cohort of 33-35 wks Gestation Infants at Risk of RSV Hospitalization
University of Calgary, Calgary, Alberta
1) – epidemiology; 2) – socioeconomic status; 3) – longitudinal followup of children and infants
The association between maternal selective serotonin re-uptake inhibitor (SSRI) exposure during late pregnancy and neonatal respiratory disorders with a focus on persistent pulmonary hypertension of the newborn (PPHN)
Manuscript is being prepared
Health Sciences Centre, Winnipeg, Manitoba
Children born to mothers with diabetes in pregnancy in Manitoba: Long term educational and healthcare outcomes
Manuscript still in analysis phase
1) – Epidemiology of Chronic Kidney Disease; 2) – Renal Complications of Diabetes; 3) – Acute Kidney Injury
Analysis of resistance patterns changes practice for children on peritoneal dialysis
An evaluation of a 6 month versus 4 month steroid protocol in childhood onset nephrotic syndrome
Manuscript in progress
1.) Neuro-ophthalmology; 2.) Cerebellar disorders; 3.) MRI use in neurology
Division of Neurology
1) – Pediatric stroke; 2) – Neonatal epilepsy and HIE; 3) – Rett syndrome
Research Question: – What are the functional outcomes of neonates with stroke?; Population of patients being studied: – Manitoba neonates with stroke, N=60; Expected Outcomes – Majority does better.
Database, some chart review
Research Question: – What are the clinical and radiological outcomes of children with posterior circulation stroke in an international multicentre registry?; Population of patients being studied: – N= 80-100; Expected Outcomes – Outcomes are dependent on underlying etiology/diagnosis.
Research Question: – What are the hypercoagulable risk factors for the first cerebral ischemic stroke onset and for the recurrence of thromboembolic events in neonates with ischemic stroke in Manitoba.; Population of patients being studied: – N=100; Expected Outcomes – Neonates often do not have hypercoagulable risk factors and if they do, their presence predicts increased risk of recurrence.
To describe the phenotypic variability seen in patients diagnosed with Rett syndrome who are currently living in Manitoba
BC Children’s Hospital, Vancouver, British Columbia
Predictors of poor outcomes following early neonatal seizure in term infants
Pain in childhood
Research Question: – Verbal anchors for pediatric self-report scales of pain intensity; Population of patients being studied: – Age 5 to 12, post-op or undergoing painful procedure; Expected Outcomes – Improvement of existing self-report pain intensity measures. Source of Data: Data collection
Research Question: – Simplifying self-report measures of pain intensity for preschool-age children; Population of patients being studied: – Age 3 to 6 years; post-op or undergoing painful procedure; Expected Outcomes – Creation of new self-report pain scale for young children. Source of Data: See http://www.pubmed.gov/23773343 (J Pain, 2013)
Three (plus ~30 PhD students) — all through University of Saskatchewan
1.) Blood and Marrow Transplantation; 2.) Primary Immunodeficiency Disorders – Transplant; 3.) Pediatric Oncology
Incidence, Morbidity, and Survival in First Nations Children with Cancer In Manitoba
Manuscript has been submitted and revised with minor revisions to Pediatric Blood and Cancer (it should be published without problem).
Hospital For Sick Children, Pediatric Hematology-Oncology, Toronto, Ontario
Heterozygous IKBKB mutations in First Nations Children Admitted to Children’s Hospital with Serious Infections
Project just starting. No data yet.
University of Manitoba, Winnipeg, Manitoba
1) – Basic Science Lung development and CDH; 2) – Experimental fetal therapeutic interventions
Research Question: – Role of microRNAs in lung development and CDH; Population of patients being studied: – CDH patients and/or rats from animal model for CDH; Expected Outcomes – Explain abnormal lung development and CDH.
Research Question: – Systematic review of basic science research and its translation into clinical practice; Population of patients being studied: – Literature review of patients with CDH; Expected Outcomes – Demonstrate value of basic science research in CDH.
miR-200b and CDH
Abstract and presentation at conference. Manuscript has not been published yet
Abstract and presentation at conference. manuscript can be found here
AVATAR trial: rct for laparoscopic wound vac dressing
1) – Evidence-Based Guidelines; 2) – Prevention of unnecessary investigations, intervention and follow up of Ped Urology conditions
Two/year on rotation, but intermittent exposure to 10 residents/year in Urology
Jason Archambault (Urology Resident)
Vaginal entrapment of bathwater – a source of extra-urethral incontinence
Presentation at conference and manuscript that can be found here
Western University, London, Ontario
1) – Pharmacogenomics; 2) – Drug safety and Pharmacoepidemiology; 3) – Hospitalist Medicine
Research Question: – Characteristics of SJS and TEN patients, and relations to medication use; Population of patients being studied: – children of all ages between 2000 and 2013; Expected Outcomes – Epidemiology of serious skin infections in Manitoba, possible initiation of pharmacogenetic evaluation.
Research Question: – Relation between ototoxicity and sildenafil in children; Population of patients being studied: – pediatric patients treated with sildenafil or similar drugs; Expected Outcomes – Finding an association between sildenafil and ototoxicity may warrant more intensive hearing screening.