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Biology of Breathing

In March 2003 the Biology of Breathing (BoB) Theme became the first theme-based research group launched at the Children\’s Hospital Research Institute of Manitoba. Formation of the Biology of Breathing consolidated a broad spectrum of local research strength in pediatric lung health and disease.

Biology of Breathing Mission:

To improve child health and reduce the burden of lung diseases in children through outstanding research and research training with strong local, national and international alliances that contribute to the development of new insight that supports safe and effective treatment, prevention, and accurate diagnosis.

Biology of Breathing Vision:

The Biology of Breathing Theme is recognized as a world-class multi-disciplinary group for basic science and clinical research and research training in pediatric pulmonary biology with capacity to foster initiatives leading to improved health of children in Manitoba.

Biology of Breathing includes: more than 15 principal investigators and collaborating investigators working in concert to carry out world-class research in pediatric pulmonary disorders; five core research facilities that provide capacity spanning molecular biology and lung physiology assessment; and offers an interactive, multi-disciplinary training program for basic and clinical trainees that is linked to nationally supported research training networks.

Biology of Breathing includes four research areas of broad and complementary scope:

  • Asthma Prevention, Diagnosis, and Treatment
  • Smooth Muscle Biology in Lung Health and Disease
  • Novel Animal Models of Human Lung Disease
  • Biology and Disease in the Developing Lung

Researchers and trainees perform specific cutting edge clinical and basic research projects on:

  • cell and molecular mechanisms for airway inflammation
  • airway smooth muscle mechanics and cell physiology
  • epidemiology of asthma and its risk factors in infants and children
  • consequences of airway inflammation on lung function and airway remodeling
  • pathogenesis and treatment of persistent pulmonary hypertension of the newborn
  • oxidative stress, tobacco smoke and pathogen exposure in lung development and surfactant function
  • breathing sounds and development of technologies to assess infant lung function
  • immunological mechanisms in the development of asthma and its exacerbation
  • development of novel inflammation-based vaccines to treat allergic disorders in the lungs
  • treatment of apnea of the newborn

For additional information about the Biology of Breathing Research Theme, please contact:
Dr. Andrew J. Halayko, Theme Leader

Phone: (204) 787-2062

Email: andrew.halayko@umanitoba.ca